As you rigorously prepare and research leading into each week of DFS, injuries are always going to change the landscape. “Next Man Up” is a series that examines players who are now being propelled into the starting role (thus creating a larger opportunity for that player), whether it be via injury, or simply a change to the depth chart.

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This is the first time I can remember a situation like this. A lot of you (including myself) are probably playing in a season-long championship this week without Odell Beckham Jr.

Although I totally stand by the NFL sitting him down for a game, man does it suck knowing that your first-round pick who got you to this point is going to miss the most important matchup. Of course, if you’re smart and also play DFS, the pain is not quite as severe.

Nobody is going to step in and put up the numbers that OBJ has so far this season — 91 catches, 1,396 yards, 13 TDs — but there are some great replacement options both on DK, or if you need a last minute waiver add in season-long.

The first place to look? Just ask Giants head coach Tom Coughlin where he thinks the ball will go in OBJ’s absence: “Rueben comes to mind.”

Rueben Randle — WR, New York Giants

Rueben Randle has had a solid season as the No. 2 option behind Beckham, tallying 638 yards and six touchdowns on 51 receptions overall. Randle is coming off back to back games with a touchdown, and has reached the end zone in four of New York’s last six games. He should see a significant bump in targets this week. 10+ is probably reasonable.

If you don’t have a deep bench at WR, Randle is a must add for championship week. But at a mere $3,500, Randle is also looking like a no brainer to use in your DK lineups when he faces the Vikings on SNF as Eli Manning’s top option.

Losing a player like Beckham has a trickle down effect, though. Like I said, no one player can replace him. So here are a couple of other guys to consider while making your lineups (or looking for a desperate season-long championship play).

Dwayne Harris — WR, New York Giants

Harris hasn’t scored a receiving touchdown since Week 10 vs. the Patriots, but he had a great game — 6 catches for 82 yards. He’s been a very “hit or miss” fantasy play all season, but if there’s a week to believe he’ll hit, it’s now. The opportunity is as big as it will ever be for Harris. Factor in that he also does some work in the return game, and there’s a whole lot of upside here at just $3,000.

Will Tye — TE, New York Giants

Tye has become a big part of the Giants’ offense lately, and his DK price (somewhat) reflects it. He’s risen from the minimum price tag of $2,500 up to $3,500 in the last month, thanks to five straight games with 10+ DK points. Tye is coming off his best two games of the season — both five catch games with a touchdown. Even though he’s not at all the same type of weapon as Beckham, Manning could look to play it safe and use Tye on his short routes more often than usual.

Anything is in play in this game for the Giants, but one of these three guys is more than likely going to go off for a big night with one of the most dangerous receivers in the league sidelined for a huge game.

Find me on Twitter @julianedlow